Hoofprint Biome Raises $15M in a Series A Round

The funding was led by SOSV, with participation from Amazon’s Climate Pledge Fund, Breakthrough Energy Fellows, and Alexandria Venture Investments.

Creds: FreePik - A cow after Hoofprint Biome news
Creds: FreePik - A cow after Hoofprint Biome news

Hoofprint Biome is developing an enzyme-based feed additive that reduces methane output created in the gut of ruminant animals during digestion.

Low-Cost, Scalable Fermentation Process 

The additive product was made through a low-cost, scalable fermentation process and builds on the established use of enzymes in livestock nutrition.

Hoofprint Biome’s Founders and Their Vision 

The company was founded in 2023 by Scott Collins and Kathryn Polkoff, who both have extensive backgrounds in biotechnology and animal science.

Streamlining Feed Efficiency with Enzyme Technology

"Our enzymes are designed to prevent the release of methane in the rumen," said Kathryn Polkoff, CEO of Hoofprint Biome. "But that's only the beginning. By using these enzymes to reshape the rumen microbiome, we can redirect energy flows for better feed efficiency—more milk in dairy cows, more weight gain in beef."

Innovative Microbiome Technology for Livestock

"Nature has spent millions of years evolving proteins as tools to regulate microbial growth. Biotechnology and artificial intelligence have finally gotten to the point where we can actually turn nature's tools into viable commercial products," says Scott Collins, the Chief Scientific Officer at Hoofprint Biome. "Our technology platform identifies and optimizes these proteins to precisely shape microbiomes."